Pharmachologic effect Aldactone 100mg
Aldactone 100mg Potassium-magnesium diuretic. It is a competitive aldosterone antagonist on the effect on the distal nephron (competes for binding sites on the cytoplasmic protein receptors, reduces the synthesis of permeases in the aldosterone-dependent portion of the collecting tubules and distal tubules), increases the excretion of Na +, Cl- and water and reduces the excretion of K + and urea, reduces titrated acidity of urine. Increased diuresis causes a hypotensive effect, which is not constant. The hypotensive effect does not depend on the level of renin in the blood plasma and does not manifest itself in normal blood pressure.
The diuretic effect is manifested at 2-5 days of treatment.
Pharmacokinetics Aldactone 100mg
After ingestion is absorbed from the gastrointestinal tract, the absorption is 90%. Metabolized in the liver, the main active metabolite is canrenone.
T1 / 2 is 13-24 hours. It is mainly excreted by the kidneys, a certain amount is excreted in the bile.
Patients receive the drug orally. In the treatment of essential hypertension, the drug is used in a dosage of from 50 to 100 mg once. With a low efficacy of the drug in the initial dosage, a gradual (once every two weeks) increase in the dose of the drug to 300 mg is possible.
|Package||100 mg/tab. (30 tab.)|